Witryna2 lip 2024 · The patient’s CL CR was 11 mL/min (severely impaired renal function); C max was 125 µg/mL (after the 11th and 12th infusions) and C trough was 37 µg/mL (just before the 12th infusion). Treatment was well tolerated in both patients and no substantial toxicity was detected. WitrynaCLP257 restored impaired Cl(-) transport in neurons with diminished KCC2 activity. The compound rescued KCC2 plasma membrane expression, renormalized stimulus-evoked responses in spinal nociceptive pathways sensitized after nerve injury and alleviated hypersensitivity in a rat model of neuropathic pain. Oral efficacy for analgesia …
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Chloride extrusion enhancers as novel therapeutics for ... - PubMed
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