WebA novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for “smart” small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells Guanhua Li,1,2 Zuojun Hu,1 Henghui Yin,1 Yunjian Zhang,1 Xueling Huang,1 Shenming Wang,1 Wen Li2 … Web30 mei 2011 · Human ether-a-go-go related gene (hERG) potassium (K +) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG …
The Human Ether-a-go-go-related Gene (hERG) Potassium …
WebAN OVERVIEW ON HUMAN ETHER-A-GO-GO-RELATED GENE ASSAY Abstract hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Meer weergeven hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Meer weergeven Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to Meer weergeven Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment … Meer weergeven HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Meer weergeven A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved … Meer weergeven This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Meer weergeven The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Meer weergeven brode 25c 3305 vransko
Activation of human ether-a-go-go related gene (hERG) …
Web5 sep. 2014 · Zachariae U, Giordanetto F, Leach AG (2009) Side Chain Flexibilities in the Human Ether-a-go-go Related Gene Potassium Channel (hERG) Together with … WebOur previous study of the human ether-à-go-go related gene (hERG)-encoded K + channel (K v 11.1) supports an association between hERG and RING finger protein 207 (RNF207) variants in aggravating the onset and severity of LQTS, specifically T613M hERG (hERG T613M) and RNF207 frameshift (RNF207 G603fs) mutations. WebClonal somato-mammotroph GH3/B6 cells and lactotroph MMQ cells express two (erg1, erg2) of the three cloned rat ether-à-go-go-related gene (erg) K channel subunits. To … tehmina urdu name meaning