WebApr 9, 2024 · Franco et al. (1999) presented evidence that the homozygous state for the V34L mutation is a strong protective factor against venous thrombosis (see 188050) in a study of 189 patients with deep venous thrombosis and 187 controls. V34L was detected in 38.6% of the patients and in 41.2% of controls. WebAug 1, 2000 · Factor XIII on activation by thrombin cross-links fibrin. A common polymorphism Val to Leu at position 34 in the FXIII A subunit is under investigation as a …
The Val34Leu genetic variation in the A Subunit of …
WebDec 1, 2001 · Recently, a common polymorphism of the FXIIIA gene, which is characterized by a Val→Leu exchange at amino acid position 34 (FXIII Val34Leu) 3 amino acids from the thrombin activation site, has been identified. 6,7 The Leu allele has been associated with decreased risk of stroke, myocardial infarction, and deep vein thrombosis 8–14 and ... WebResults: FXIII levels were higher for homozygous carriers of the FXIII polymorphism in comparison with wild-type 34 Val/Val and heterozygous 34 Val/Leu. Interestingly, persons homozygous for the FXIII Val34Leu polymorphism had lower monocyte and neutrophil counts throughout the observation period, yet prothrombin fragment 1+2 and D-dimer … lyndale assisted living
The factor XIII-A Val34Leu polymorphism decreases whole blood …
WebApr 1, 2006 · Hancer et al. (21) in MI patients study supported the hypothesis that val 34 Leu polymorphism in FXIII gene has a protective effect against MI. Mainly the genotype 34 Leu of FXIII showed ... WebAim: Characterize effects of FXIII-A Val34Leu polymorphism and fibrinogen on whole blood clots. Methods: We isolated platelet-poor plasmas from human donors (FXIII Val/Val, FXIII Val/Leu, FXIII Leu/Leu), reconstituted plasmas with platelets and RBCs, and triggered clotting. We assessed contributions of gender, age, clotting times, thrombin ... WebApr 1, 1998 · Background and Purpose—A common G-to-T point mutation (Val 34 Leu) in exon 2 of the α-subunit of the factor XIII is strongly negatively associated with the … kino heilbronn arthouse