WebCathepsin D is a lysosomal protease and increased tissue expression has been correlated with poorer outcome in a number of other cancers, except RCC, where the opposite relationship has been reported [179]. From: Biomarkers of Kidney Disease (Second Edition), 2024 View all Topics Add to Mendeley About this page Cathepsin D Martin Fusek, ... WebDec 21, 2024 · 6QBG, 6QBH, 6QCB. PubMed Abstract: Human cathepsin D (CatD), a pepsin-family aspartic protease, plays an important role in tumor progression and metastasis. Here, we report the development of biomimetic inhibitors of CatD as novel tools for regulation of this therapeutic target. We designed a macrocyclic scaffold to mimic the …
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WebBackground: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different physiological processes and signaling pathways, is accountable for metabolic breakdown of intracellular proteins, the activation of growth factors, hormones, and precursors of enzyme, the processing of antigens, enzyme inhibitors and activators and the regulation of … play skyblock minecraft
Progranulin-mediated deficiency of cathepsin D results in FTD and NCL ...
WebMay 10, 2024 · The deficiency of progranulin affects the specific activity of several lysosomal enzymes, including cathepsin D (CTSD) and β-glucocerebrosidase (GCase) in the brain either by directly mediating... WebJul 28, 2015 · Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease for α-syn clearance; however, the protease alone only generates amyloidogenic C terminal-truncated species (e.g., 1-94, 5-94), implying that other proteases and/or environmental factors are needed to facilitate degradation and to avoid α-syn ... WebCathepsin D is produced as an inactive enzyme, called a preproenzyme, which has extra protein segments attached. These segments must be removed, followed by additional processing steps, for the enzyme to become active. The mature, active cathepsin D enzyme is made up of two parts, one light chain and one heavy chain. play skyblock online