Cisplatin binding protein
WebThe binding to rat serum proteins shows no apparent specificity, with albumin retaining the greatest fraction of the label (40-55%). The binding is neither instantaneous nor linear with time. Upon intravenous administration to rats of a rat serum protein bound 195mPt-cisplatin, the label remains bound to the proteins while in the blood. WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …
Cisplatin binding protein
Did you know?
WebDec 22, 2007 · D and E carboxylate oxygen atoms and M thioether sulfur atoms are kinetically preferred binding sites for cisplatin in competition with DNA nucleobase nitrogens, and it has been postulated that initial κ S coordination by methionine-containing proteins may play a role in the mechanism of the anticancer drug [ 14, 15 ]. WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). ... belonging to the USP protein family, reacts with the 26S proteasome complex and …
WebNational Center for Biotechnology Information WebJun 3, 2013 · To identify proteins that bind to cisplatin, we synthesized two different platinum-agarose conjugates, one with two amino groups and another with two chlorides attached to platinum that are available for …
WebThese results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. ... Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and … WebCisplatin-bound DNA impairs the normal functions of proteins involved in DNA repair and transcription. The nucleotide excision repair (NER) process typically removes bulky abnormalities caused by chemicals or …
WebThe protein binding rates (PBR) of platinum-containing agents cisplatin (CDDP), carboplatin (CBDCA) and oxaliplatin (L-OHP) have been reported as 98%, 25-50% and 98%, respectively. To investigate the protein-binding properties of albumin with cisplatin, carboplatin and oxaliplatin, inductively coupl … cryptocurrency in india research paperWebFeb 1, 2016 · Cisplatin owns the most tendency to plasma proteins-so that after a few hours, up to 90% of the drug is bound to protein [19, 20]. Carboplatin possesses the … during fermentation a wine will becomeWeb40 rows · May 15, 2016 · Pt metalation of protein by cisplatin has been studied for a long time, but only very recently ... during deficiency of oxygen in human beingsWebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic … cryptocurrency in india wazirxWebJun 15, 2024 · Wang et al. indicated that miR-17 targets c-Jun activation domain binding protein 1 (JAB1) to promote tumor growth and cisplatin (DDP) resistance of TNBC . As far as we know, chemotherapy is the standard therapeutic strategy for TNBC, and DDP is the most widely used chemotherapeutic drug for solid tumors. during forced exhalationWebMar 29, 2024 · Cisplatin binds to the copper-binding sites in the N-terminal domain of ATP7B; this binding may be an essential step of cisplatin detoxification involving copper ATPases. COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux. cryptocurrency in india newsWebC-terminal binding protein‑2 (CtBP2) is a transcriptional co-repressor that is associated with tumorigenesis and tumor progression. It has been reported to predict a poor … during filtration materials move from