WebPK lxV" på »ö5[G2-23-2-01] À¯ÀüüÆíÁý °íµµÈ, Çٽɿøõ±â¼ú °³¹ß.hwpì[ o ïŒï=÷žsÏ9¿ýž{ÎÕD þ”œµù3ä÷’ d9„à ... WebMar 6, 2024 · Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the form of micronuclei and chromatin bridges. These structures are detected by the nucleic acid sensor cGAS, leading to the production of the second …
The cGAS-STING pathway: a therapeutic target in …
WebThe connection between CIN and the cGAS-STING pathway raises the exciting possibility that chromosome segregation errors could serve as a trigger of immune editing during the early steps of tumorigenesis. … WebAug 31, 2024 · The role that cGAS-STING signaling exerts on CIN tumors is both complex and paradoxical. On one hand, the cGAS-STING axis promotes the clearance of CIN tumors through recruitment of immune cells, thus suppressing tumor progression. On the other hand, the cGAS-STING pathway has been described to be the major regulator in the … how to roll and tie brisket
Nuclear cGAS: sequestration and beyond Protein & Cell Oxford …
WebAug 9, 2024 · Some recent studies show that CIN is also involved in the crosstalk between a tumor and its surrounding microenvironment, which is mediated by the cGAS-STING pathway (Bakhoum et al., 2024; Hong et al., 2024; Nassour et al., 2024). cGAS recognizes dsDNA in micronuclei and the localization of cGAS to micronuclei is induced by genome … WebMar 6, 2024 · The dichotomous role of CIN-driven cell-intrinsic cGAS-STING inflammatory signalling in cancer. Activation of cGAS-STING-dependent inflammatory signalling downstream of CIN can exert both tumour ... WebApr 12, 2024 · The specific tumor stage, CIN state, genotype, and basal level of cGAS-STING activation will likely determine the therapeutic responses of the host to STING agonists or antagonists. Therefore, a better understanding of the careful selection of patients is needed to resolve which patients will benefit from pharmacologic therapy that activates … northern illinois basketball scores